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There are number of reported cases that people taking Meridia increases the risk of strokes and heart attacks especially those with history of cardiovascular diseases. The most adverse effects that have been reported are: dry mouth, strange taste in the mouth, increased appetite, nausea, upset stomach, constipation, menstrual cramps, trouble sleeping, dizziness, flushing and muscle pain. There are adverse effects that are infrequent but may require serious medical attention: paresthesia, cardiac arrhythmias and mood changes. The adverse effects that require urgent medical treatment are seizures, hematesis, abnormal bruising, jaundice, fever, chest pain, hemiplegia, abnormal vision and edema.
Currently, there have been no case related to pulmonary hypertension though related compounds have indicated this rare but clinically important problem.
Meridia has clinically important interactions. Combining Meridia with MAO inhibitors is not recommended because it can increase the risk of serotonin syndrome, a rare but serious side effect. It should not be used within two weeks of taking or stopping MAO inhibitors. A drug that treats migraine as well as opioids may also increase the risk of serotonin syndrome.
The recommended dose of this drug is 10 mg once daily and it can be increased up to 15 mg daily after 4 weeks if it proves insufficient. Studies are currently ongoing into the reports of heart failure, sudden death, gastrointestinal problems and renal failure. In 2005, FDA didn’t attempted to withdraw the drug despite a petition was made by Mr. Ralph Nader but was part of a Senate hearing. FDA “whistlerblower” said in the Senate hearing that Meridia may be more dangerous than it is indicated for.
A large randomized-controlled study was made with 10,742 patients whether Meridia reduces the risk of cardiovascular complications in patients having a history of heart disease and after six week treatment, they concluded that Meridia appears to be effective, safe and tolerable.
The FDA reviewed the data from the studies made suggesting that patients taking this drug have higher risk of cardiovascular complications than patients using a placebo. The study mentioned showed 11.4% in patients using Meridia while 10% in patients using a placebo.